AAVs are small, non-enveloped, single-stranded DNA viruses that were discovered in the 1960s as contaminants of adenovirus preparations. They induce limited host immune responses and are not associated with any known diseases. However, they have been found to efficiently deliver DNA cargo to many tissues in multiple animal species. Thus, AAV vectors are widely used as gene transfer tools in...

With the success of messenger RNA (mRNA) vaccines against SARS-CoV-2 and the approval of several RNA interference (RNAi) agents in recent years, the era of RNA medicine has become a reality. RNA therapeutics show great promise as the next generation of treatments for a wide array of diseases. Therefore, many efforts are underway to develop nano-vehicles that can deliver therapeutic RNA...