Q1: What is IDH2 and what does it do?
IDH2 encodes a mitochondrial enzyme involved in cellular metabolism, catalyzing the conversion of isocitrate to α-ketoglutarate while generating NADPH for redox balance.

Q2: Why is IDH2 important in cancer research?
Mutations in IDH2 can produce the oncometabolite 2-hydroxyglutarate, which disrupts normal cellular metabolism and contributes to tumor development.

Q3: How is IDH2 used in research applications?
IDH2 is widely studied in metabolic regulation, epigenetic modification, and cancer biomarker discovery, particularly in leukemia and glioma studies.